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River Song, looking at the Doctor, teary eyed.

RIVER: I can't let you die without knowing you are loved by so many, and so much, and by no one more than me.

DOCTOR: River, you and I, we know what this means. We are ground zero of an explosion that will engulf all reality. Billions on billions will suffer and die.

RIVER: I'll suffer if I have to kill you.

DOCTOR: More than every living thing in the universe?

RIVER: Yes.

The Wedding of River Song