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River opening a locked door

RORY: What did you mean? What you said to Amy. There's a worst day coming for you.

RIVER: When I first met the Doctor, a long, long time ago, he knew all about me. Think about that. An impressionable young girl and, suddenly this man just drops out of the sky and he's clever and mad and wonderful, and knows every last thing about her. Imagine what that does to a girl.

RORY: I don't really have to.

RIVER: The trouble is, it's all back to front. My past is his future. We're travelling in opposite directions. Every time we meet, I know him more, he knows me less. I live for the days when I see him, but I know that every time I do, he'll be one step further away. And the day is coming when I'll look into that man's eyes, my Doctor, and he won't have the faintest idea who I am. And I think it's going to kill me.

The Impossible Astronaut